Domperidone is practically water insoluble drug exhibiting poor dissolution and absorption. The main objective of the present study is to improve the dissolution rate of domperidone by preparation of solid dispersion using polyethylene glycol (PEG 6000) as a carrier at low and high concentration. Solid dispersions were prepared by Fusion method at different polymer ratio. The physical state and drug: polymer interaction were analyzed by Differential scanning calorometry, and infrared spectroscopy, and Scanning electron microscopy. The dissolution rate of Domperidone from solid dispersions was markedly enhanced by increasing polymer concentration. The result shows that dissolution rate of domperidone from all Physical mixture and solid dispersion was significantly higher than that of domperidone alone. The result indicated that solid dispersion 1:9 exhibited more than 90% of drug release after 20 min. DSC study showed that the degree of crystaliinity of domperidone in solid dispersion decreased when the ratio of the polymer increased, suggesting that the drug is present inside the sample in different physical state. The Fourier transform infrared spectroscopy studies showed the stability of domperidone and the absence of well defined drug polymer interaction.
Loading....